Dear Members of the ID-IRI Society,

The ID-IRI Community Acquired Bacteremia In Older Adults: International and Prospective ID-IRI Study is accepted for publication in the International Journal of Infectious Diseases, a Q1 ranked journal.https://infectdisiri.com/id-iri-2026/ Many thanks to the participants of the study.

The study had a prospective design across 72 centers in 16 countries (June to September 2024) and included 574 adults ≥65 years with confirmed CA-BSIs. Primary outcome was 30-day all-cause mortality. 30-day mortality was as high as 26.3%.

Common infection sources were urinary tract 33.7% (most frequent) and BSI of unknown origin (30.5%).

Independent Predictors of Mortality:

1.    Higher illness severity: SOFA score ≥5

2.    Severe thrombocytopenia: <50,000/µL

3.    Staphylococcus aureus bacteremia

4.    Pneumonia as source

5.    Unknown infection origin

6.    Higher comorbidity burden: elevated Charlson Comorbidity Index

Protective Factor

1.    Better functional status (higher Katz Activities of Daily Living scores) was associated with improved survival.

In conclusion, CA-BSIs in older adults carry substantial mortality risk. Outcomes are influenced by Baseline health (comorbidities, functional status), Acute severity of illness, Infecting organism, and the source.

List of Authors

Sevgi Sokulmez-Yildirim, Hakan Erdem, Handan Ankarali, Seniha Senbayrak, Elif Doyuk Kartal, Ozlem Bayrak, Aruna Poojary, Ilad Alavi Darazam, Beyza Sullu, Meltem Tasbakan, Refika Nur Kahraman¹, Halime Araz, Pinar Yuruk Atasoy, Tatjana Roganovic, Sinan Cetin, Dilek Yekenkurul, Rok Civljak, Zeynep Oktay, Ahmet Dogan, Gulay Okay, Ergys Ramosaco, Abdullah Umut Pekok, Rukiye Inan-Sarikaya, Egidia Miftode, Entela Kolovani, Fatma Amer,  Firdevs Aksoy, Homa Ghasempour, Larisa Miftode, Gergana Lengerova, Amani El-Kholy, Svjetlana Grgic,  Michael Mihailov Petrov, Sevil Alkan, Stanislav Kotsev, Maria Pishmisheva Peleva , Bahar Busra Sivrikaya, Davut Ipek, Kostadin Poposki, Massimiliano Lanzafame, Öznur Ak, Selcuk Yaylaci, Mustafa Altindis, Arzu Cennet Isik, Belgin Coskun, Esra Gurbuz,  Ghaydaa A. Shehata, Nilgun Koltuk Kaya, Ilkay Bozkurt, Ayfer Imre, Ayse Sagmak Tartar, Cigdem Yildirim, Irina Magdalena Dumitru,  Luca Mihaela Catalina, Maya Belitova, Omnia Mohamed Elnabawy Ahmed Taher, Sema Sari, Antonio Cascio, Bilal Ahmad Rahimi, Gulden Eser Karlidag, Maria Ioana Onofrei, Sevda Ozdemir Al, Sholpan Kulzhanova, Yasemin Cag, Hatice Kubra Ucar, Cumhur Ozmen, George Sebastian Gherlan, Maha Ali Gad, Nasim Akhtar, Serkan Oncu, Tarsila Vieceli, Aidos Konkayev, Aliye Esmaoglu,  Asli Kilavuz, Pinar Sirmatel Bucuk, Balint Gergely Szabo, Christian Gomez Davila, Cihan Semet, Edmond Puca, Emine Unal Evren, Hamed Azhdari Tehrani, Kumar Angamuthu, Meliha Cagla Sonmezer, Orcun Soysal, Selma Ates, Giulia Spurio, Sultan Keskin Demircan,  Taylan Onder, Fevzi Coskun Sökmen, Jordi Rello,  Anna Giammanco, Teresa Fasciana.