Community acquired CNS infections in the Northern Hemisphere

ID-IRI study, analyzing community acquired central nervous system infections in 20 countries stretching from the USA and to Hong Kong is now accepted for publication in European Journal of Clinical Microbiology & Infectious Diseases. Many thanks to our group for this project. The major remarks in the study are (p<0.05 for all):

  1. The most frequent infecting pathogens are S. pneumoniae followed by M.tuberculosis
  2. VZV and Listeria are other common pathogens in the elderly
  3. Staphylococci and Listeria resulted in frequent infections in immunocompromized pts
  4. Cryptococci are leading pathogens in HIV positives.
  5. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS Tuberculosis had a predilection to present chronic courses.
  6. L. monocytogenes, S. aureus, M.. tuberculosis, and S. pneumoniae were the most fatal infections
  7. HSV-1 had the highest sequelae
  8. Effective pneumococcal immunization and strategies to eliminate Tuberculosis are underlined.
  9. More must be done to improve diagnostic capacity.


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