VZV CNS disease analysis

We are carrying a subgroup analysis for the VZV CNS disease through ID-IRI community acquired CNS infections database  (The burden and epidemiology of community-acquired central nervous system infections: a multinational study. Eur J Clin Microbiol Infect Dis. 2017 Sep;36(9):1595-1611). We will hopefully distribute the results soon.

Info for 3 multicenter ID-IRI studies.

  1. The analysis of neurosyphilis cases: Data analysis is finished and currently we are writing the paper. We will distribute the manuscript to the participant centers within a couple of weeks.
  2. HIV stigmata and discrimination survey: The data analysis continues but it is about to be finished. We will inform on the process
  3. ID-IRI cryptococcal meningitis study: We have just submitted the paper elsewhere

Community acquired CNS infections in the Northern Hemisphere

ID-IRI study, analyzing community acquired central nervous system infections in 20 countries stretching from the USA and to Hong Kong is now accepted for publication in European Journal of Clinical Microbiology & Infectious Diseases. Many thanks to our group for this project. The major remarks in the study are (p<0.05 for all):

  1. The most frequent infecting pathogens are S. pneumoniae followed by M.tuberculosis
  2. VZV and Listeria are other common pathogens in the elderly
  3. Staphylococci and Listeria resulted in frequent infections in immunocompromized pts
  4. Cryptococci are leading pathogens in HIV positives.
  5. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS Tuberculosis had a predilection to present chronic courses.
  6. L. monocytogenes, S. aureus, M.. tuberculosis, and S. pneumoniae were the most fatal infections
  7. HSV-1 had the highest sequelae
  8. Effective pneumococcal immunization and strategies to eliminate Tuberculosis are underlined.
  9. More must be done to improve diagnostic capacity.